Combining Multiple Markers to Improve the Longitudinal Rate of Progression-Application to Clinical Trials on the Early Stage of Alzheimer’s Disease

Clinical trials on early stage Alzheimer’s disease (AD) are reaching a bottleneck because none of the current disease markers changes appreciably early in the disease process and therefore a huge sample is required to adequately power such trials. We propose a method to combine multiple markers so t...

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Autori principali: Xiong, Chengjie, van Belle, Gerald, Chen, Kewei, Tian, Lili, Luo, Jingqin, Gao, Feng, Yan, Yan, Chen, Ling, Morris, John C, Crane, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868484/
https://ncbi.nlm.nih.gov/pubmed/24363827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19466315.2012.756662
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