KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer

Intrinsic resistance to agents targeting phosphatidylinositol-3-kinase (PI3K)/AKT pathway is one of the major challenges in cancer treatment with such agents. The objective of this study is to identify the genes or pathways that can be targeted to overcome the resistance of non-small cell lung cance...

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Bibliografiske detaljer
Main Authors: Dai, Bingbing, Yoo, Suk-Yuong, Bartholomeusz, Geoffrey, Graham, Ryan A., Majidi, Mourad, Yan, Shaoyu, Meng, Jieru, Ji, Lin, Coombes, Kevin, Minna, John D., Fang, Bingliang, Roth, Jack A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868367/
https://ncbi.nlm.nih.gov/pubmed/23824739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0712
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