KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer

Intrinsic resistance to agents targeting phosphatidylinositol-3-kinase (PI3K)/AKT pathway is one of the major challenges in cancer treatment with such agents. The objective of this study is to identify the genes or pathways that can be targeted to overcome the resistance of non-small cell lung cance...

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Detalhes bibliográficos
Main Authors: Dai, Bingbing, Yoo, Suk-Yuong, Bartholomeusz, Geoffrey, Graham, Ryan A., Majidi, Mourad, Yan, Shaoyu, Meng, Jieru, Ji, Lin, Coombes, Kevin, Minna, John D., Fang, Bingliang, Roth, Jack A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868367/
https://ncbi.nlm.nih.gov/pubmed/23824739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0712
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