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A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice

Diet-induced obesity is a lifestyle-associated medical condition that increases the risk of developing cardiovascular disease, type 2 diabetes and certain types of cancer. Here we report the design of a closed-loop genetic circuit that constantly monitors blood fatty acid levels in the setting of di...

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Hlavní autoři: Rössger, Katrin, Charpin-El-Hamri, Ghislaine, Fussenegger, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868331/
https://ncbi.nlm.nih.gov/pubmed/24281397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3825
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