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Self-adjusting synthetic gene circuit for correcting insulin resistance

By using tools from synthetic biology, sophisticated genetic devices can be assembled to reprogram mammalian cell activities. Here, we demonstrate that a self-adjusting synthetic gene circuit can be designed to sense and reverse the insulin-resistance syndrome in different mouse models. By functiona...

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Podrobná bibliografie
Vydáno v:Nat Biomed Eng
Hlavní autoři: Ye, Haifeng, Xie, Mingqi, Xue, Shuai, Charpin-El Hamri, Ghislaine, Yin, Jianli, Zulewski, Henryk, Fussenegger, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412959/
https://ncbi.nlm.nih.gov/pubmed/28480128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-016-0005
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