Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A

It is essential to improve therapies for controlling excessive bleeding in patients with haemorrhagic disorders. As activated blood platelets mediate the primary response to vascular injury, we hypothesize that storage of coagulation Factor VIII within platelets may provide a locally inducible treat...

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Detalhes bibliográficos
Main Authors: Du, Lily M., Nurden, Paquita, Nurden, Alan T., Nichols, Timothy C., Bellinger, Dwight A., Jensen, Eric S., Haberichter, Sandra L., Merricks, Elizabeth, Raymer, Robin A., Fang, Juan, Koukouritaki, Sevasti B., Jacobi, Paula M., Hawkins, Troy B., Cornetta, Kenneth, Shi, Qizhen, Wilcox, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868233/
https://ncbi.nlm.nih.gov/pubmed/24253479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3773
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