Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with...

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Detalles Bibliográficos
Publicado en:Comp Med
Autores principales: Lozier, Jay N, Kloos, Mark T, Merricks, Elizabeth P, Lemoine, Nathaly, Whitford, Margaret H, Raymer, Robin A, Bellinger, Dwight A, Nichols, Timothy C
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for Laboratory Animal Science 2016
Materias:
Canine Model
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073066/
https://ncbi.nlm.nih.gov/pubmed/27780008
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