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Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with...

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Publicado no:Comp Med
Main Authors: Lozier, Jay N, Kloos, Mark T, Merricks, Elizabeth P, Lemoine, Nathaly, Whitford, Margaret H, Raymer, Robin A, Bellinger, Dwight A, Nichols, Timothy C
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Laboratory Animal Science 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073066/
https://ncbi.nlm.nih.gov/pubmed/27780008
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