A Homology Based Model and Virtual Screening of Inhibitors for Human Geranylgeranyl Transferase 1 (GGTase1)

Protein prenylation is a post translational modification that is indispensable for Ras–Rho mediated tumorigenesis. In mammals, three enzymes namely protein farnesyltransferase (FTase), geranylgeranyl transferase1 (GGTase1), and geranylgeranyl transferase2 (GGTase2) were found to be involved in this...

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Detalhes bibliográficos
Main Authors: Thippanna, Mallikarjuna, Subramani, Parasuraman Aiya, Lomada, Dakshayani, Narala, Venkata Ramireddy, Reddy, Madhava C
Formato: Artigo
Idioma:Inglês
Publicado em: Biomedical Informatics 2013
Assuntos:
Hypothesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867650/
https://ncbi.nlm.nih.gov/pubmed/24391360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630009973
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