A Homology Based Model and Virtual Screening of Inhibitors for Human Geranylgeranyl Transferase 1 (GGTase1)

Protein prenylation is a post translational modification that is indispensable for Ras–Rho mediated tumorigenesis. In mammals, three enzymes namely protein farnesyltransferase (FTase), geranylgeranyl transferase1 (GGTase1), and geranylgeranyl transferase2 (GGTase2) were found to be involved in this...

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Bibliografiske detaljer
Main Authors: Thippanna, Mallikarjuna, Subramani, Parasuraman Aiya, Lomada, Dakshayani, Narala, Venkata Ramireddy, Reddy, Madhava C
Format: Artigo
Sprog:Inglês
Udgivet: Biomedical Informatics 2013
Fag:
Hypothesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867650/
https://ncbi.nlm.nih.gov/pubmed/24391360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630009973
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