A Homology Based Model and Virtual Screening of Inhibitors for Human Geranylgeranyl Transferase 1 (GGTase1)

Protein prenylation is a post translational modification that is indispensable for Ras–Rho mediated tumorigenesis. In mammals, three enzymes namely protein farnesyltransferase (FTase), geranylgeranyl transferase1 (GGTase1), and geranylgeranyl transferase2 (GGTase2) were found to be involved in this...

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Autori principali: Thippanna, Mallikarjuna, Subramani, Parasuraman Aiya, Lomada, Dakshayani, Narala, Venkata Ramireddy, Reddy, Madhava C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biomedical Informatics 2013
Soggetti:
Hypothesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867650/
https://ncbi.nlm.nih.gov/pubmed/24391360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630009973
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