A Homology Based Model and Virtual Screening of Inhibitors for Human Geranylgeranyl Transferase 1 (GGTase1)

Protein prenylation is a post translational modification that is indispensable for Ras–Rho mediated tumorigenesis. In mammals, three enzymes namely protein farnesyltransferase (FTase), geranylgeranyl transferase1 (GGTase1), and geranylgeranyl transferase2 (GGTase2) were found to be involved in this...

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Библиографические подробности
Главные авторы: Thippanna, Mallikarjuna, Subramani, Parasuraman Aiya, Lomada, Dakshayani, Narala, Venkata Ramireddy, Reddy, Madhava C
Формат: Artigo
Язык:Inglês
Опубликовано: Biomedical Informatics 2013
Предметы:
Hypothesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867650/
https://ncbi.nlm.nih.gov/pubmed/24391360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630009973
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