Population-based analysis of Alzheimer’s disease risk alleles implicates genetic interactions

BACKGROUND: Reported odds ratios and population attributable fractions (PAF) for late-onset Alzheimer’s disease (LOAD) risk loci (BIN1, ABCA7, CR1, MS4A4E, CD2AP, PICALM, MS4A6A, CD33, and CLU) come from clinically ascertained samples. Little is known about the combined PAF for these LOAD risk allel...

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Main Authors: Ebbert, Mark T. W., Ridge, Perry G., Wilson, Andrew R., Sharp, Aaron R., Bailey, Matthew, Norton, Maria C., Tschanz, JoAnn T., Munger, Ronald G., Corcoran, Christopher D., Kauwe, John S. K.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867586/
https://ncbi.nlm.nih.gov/pubmed/23954108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.07.008
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