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KINETIC AND STRUCTURAL INVESTIGATIONS INTO THE ALLOSTERIC AND PH EFFECT ON SUBSTRATE SPECIFICITY OF HUMAN EPITHELIAL 15-LIPOXYGENASE-2

Lipoxygenases, important enzymes in inflammation, can regulate their substrate specificity by allosteric interactions with its own hydroperoxide products. In the current work, addition of both 13-(S) hydroxy-9Z,11E-octadecadienoic acid (13-(S)-HODE) and 13-(S)-hydroperoxy-6Z,9Z,11E-octadecatrienoic...

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Hlavní autoři: Joshi, Netra, Hoobler, Eric K., Perry, Steven, Diaz, Giovanni, Fox, Brian, Holman, Theodore R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866584/
https://ncbi.nlm.nih.gov/pubmed/24171444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4010649
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