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Argonaute-3 activates the let-7a passenger strand microRNA

MicroRNA duplices are separated into a guide and a passenger strand. By convention, the guide represents the active microRNA while the passenger is supposedly degraded. However, passenger strands also emerge as active microRNAs. It is unknown whether the guide-to-passenger-strand ratio can be active...

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Autori principali: Winter, Julia, Diederichs, Sven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866245/
https://ncbi.nlm.nih.gov/pubmed/24100239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.26424
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