Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma

Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cells against tumors. However, the potential for inser...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Budde, Lihua E., Berger, Carolina, Lin, Yukang, Wang, Jinjuan, Lin, Xubin, Frayo, Shani E., Brouns, Shaunda A., Spencer, David M., Till, Brian G., Jensen, Michael C., Riddell, Stanley R., Press, Oliver W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2013
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866194/
https://ncbi.nlm.nih.gov/pubmed/24358223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082742
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