Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma

Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cells against tumors. However, the potential for inser...

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Detalhes bibliográficos
Main Authors: Budde, Lihua E., Berger, Carolina, Lin, Yukang, Wang, Jinjuan, Lin, Xubin, Frayo, Shani E., Brouns, Shaunda A., Spencer, David M., Till, Brian G., Jensen, Michael C., Riddell, Stanley R., Press, Oliver W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866194/
https://ncbi.nlm.nih.gov/pubmed/24358223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082742
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