Oleanane Triterpenoid CDDO-Me Inhibits Growth and Induces Apoptosis in Prostate Cancer Cells by Independently Targeting Pro-Survival Akt and mTOR

BACKGROUND: Synthetic triterpenoids are potent anticancer agents, but their therapeutic efficacy or mechanism of action for prostate cancer has not been investigated. The goal of this study was to determine the antitumor activity and the mechanism of action of methyl-2-cyano-3,12-dioxooleana-1,9(11)...

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Hlavní autoři: Deeb, Dorrah, Gao, Xiaohua, Jiang, Hao, Dulchavsky, Scott A., Gautam, Subhash C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865612/
https://ncbi.nlm.nih.gov/pubmed/19189297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.20937
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