Synthetic Oleanane Triterpenoid, CDDO-Me, Induces Apoptosis in Ovarian Cancer Cells by Inhibiting Prosurvival AKT/NF-κB/mTOR Signaling

Synthetic oleanane triterpenoids are novel agents which have shown strong antitumorigenic activity against a wide range of cancer types in vitro. The objective of the present study was to determine the anticancer activity of methyl-2-cyano-3, 12-dioxooleana-1, 9(11)-dien-28-oate (CDDO-Me) derived fr...

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Hauptverfasser: GAO, XIAOHUA, LIU, YONGBO, DEEB, DORRAH, ARBAB, ALI S., GUO, AUSTIN M., DULCHAVSKY, SCOTT A., GAUTAM, SUBHASH C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711099/
https://ncbi.nlm.nih.gov/pubmed/22110186
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