Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Complement is viewed as a critical serum-operative component of innate immunity, with processing of its key component, C3, into activation fragments C3a and C3b confined to the extracellular space. We report here that C3 activation also occurred intracellularly. We found that the T cell-expressed pr...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liszewski, M. Kathryn, Kolev, Martin, Le Friec, Gaelle, Leung, Marilyn, Bertram, Paula G., Fara, Antonella F., Subias, Marta, Pickering, Matthew C., Drouet, Christian, Meri, Seppo, Arstila, T. Petteri, Pekkarinen, Pirkka T., Ma, Margaret, Cope, Andrew, Reinheckel, Thomas, Rodriguez de Cordoba, Santiago, Afzali, Behdad, Atkinson, John P., Kemper, Claudia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865363/
https://ncbi.nlm.nih.gov/pubmed/24315997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.10.018
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