Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection

Chronic inappropriate immune activation is the central defect-driving loss of CD4(+) T helper cells and progression to AIDS in persons with HIV-1 infection, but the mechanisms remain controversial. We examined key regulatory invariant receptor natural killer T (iNKT) cells in the gut, the largest re...

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Autori principali: Ibarrondo, FJ, Wilson, SB, Hultin, LE, Shih, R, Hausner, MA, Hultin, PM, Anton, PA, Jamieson, BD, Yang, OO
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865278/
https://ncbi.nlm.nih.gov/pubmed/23149661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.101
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