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Global structures of IgG isotypes expressing identical variable regions

Until relatively recently the immunoglobulin molecule was viewed as composed of two independent domains comprised of the variable (V) and constant (C) regions. However, recent work has established that the C region mediates allosteric changes in the V region that can influence specificity and affini...

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Détails bibliographiques
Auteurs principaux: Eryilmaz, Ertan, Janda, Alena, Kim, Jungwook, Cordero, Radames J.B., Cowburn, David, Casadevall, Arturo
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864969/
https://ncbi.nlm.nih.gov/pubmed/23911417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2013.06.006
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