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Global structures of IgG isotypes expressing identical variable regions
Until relatively recently the immunoglobulin molecule was viewed as composed of two independent domains comprised of the variable (V) and constant (C) regions. However, recent work has established that the C region mediates allosteric changes in the V region that can influence specificity and affini...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864969/ https://ncbi.nlm.nih.gov/pubmed/23911417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2013.06.006 |
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