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Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy

Mitochondria dysfunction plays a significant role in the apoptosis of retinal cells. Diabetes activates retinal matrix metalloproteinases (MMP-9 and MMP-2), damages retinal mitochondria and activates the apoptotic machinery. This study is to investigate the temporal relationship between the activati...

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Bibliografiske detaljer
Main Authors: Santos, Julia M., Tewari, Shikha, Lin, Jonathan Y., Kowluru, Renu A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864795/
https://ncbi.nlm.nih.gov/pubmed/23891690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.07.066
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