Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

AIMS: The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1(+/−) mice, having a 50% reduction in O...

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Bibliographic Details
Main Authors:	Piquereau, Jerome, Caffin, Fanny, Novotova, Marta, Prola, Alexandre, Garnier, Anne, Mateo, Philippe, Fortin, Dominique, Huynh, Le Ha, Nicolas, Valérie, Alavi, Marcel V., Brenner, Catherine, Ventura-Clapier, Renée, Veksler, Vladimir, Joubert, Frédéric
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3863708/ https://ncbi.nlm.nih.gov/pubmed/22406748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs117
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Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

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