Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

AIMS: The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1(+/−) mice, having a 50% reduction in O...

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Detalhes bibliográficos
Main Authors: Piquereau, Jerome, Caffin, Fanny, Novotova, Marta, Prola, Alexandre, Garnier, Anne, Mateo, Philippe, Fortin, Dominique, Huynh, Le Ha, Nicolas, Valérie, Alavi, Marcel V., Brenner, Catherine, Ventura-Clapier, Renée, Veksler, Vladimir, Joubert, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863708/
https://ncbi.nlm.nih.gov/pubmed/22406748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs117
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