Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

AIMS: The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1(+/−) mice, having a 50% reduction in O...

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Autori principali: Piquereau, Jerome, Caffin, Fanny, Novotova, Marta, Prola, Alexandre, Garnier, Anne, Mateo, Philippe, Fortin, Dominique, Huynh, Le Ha, Nicolas, Valérie, Alavi, Marcel V., Brenner, Catherine, Ventura-Clapier, Renée, Veksler, Vladimir, Joubert, Frédéric
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863708/
https://ncbi.nlm.nih.gov/pubmed/22406748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs117
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