טוען...
Transition State Structures and the Roles of Catalytic Residues in GAP-Facilitated GTPase of Ras As Elucidated by (18)O Kinetic Isotope Effects
Ras-catalyzed guanosine 5′ triphosphate (GTP) hydrolysis proceeds through a loose transition state as suggested in our previous study of (18)O kinetic isotope effects (KIE) [Du, X. et al. ((2004)) Proc. Natl. Acad. Sci. U.S.A. 101, 8858–8863]. To probe the mechanisms of GTPase activation protein (GA...
שמור ב:
Main Authors: | , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
2009
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3862183/ https://ncbi.nlm.nih.gov/pubmed/19610677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802359b |
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