The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis

Insulin-like growth factor 2 (IGF2), a developmentally regulated and maternally imprinted gene, is frequently overexpressed in pediatric cancers. Although loss of imprinting (LOI) at fetal promoters contributes to increased IGF2 in tumors, the magnitude of IGF2 expression suggests the involvement of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Liu, Mingzhu, Roth, Anna, Yu, Min, Morris, Robert, Bersani, Francesca, Rivera, Miguel N., Lu, Jun, Shioda, Toshihiro, Vasudevan, Shobha, Ramaswamy, Sridhar, Maheswaran, Shyamala, Diederichs, Sven, Haber, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861668/
https://ncbi.nlm.nih.gov/pubmed/24298054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.224170.113
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados