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12/15-Lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia

Oxidative stress involving pre-myelinating oligodendrocytes (OLs) is a major factor in the pathogenesis of preterm white matter injury. In animal and cell culture studies, activation of the lipid-oxidizing enzyme 12/15-lipoxygenase (12/15-LOX) plays a central role as an inflammatory mediator in the...

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Detalhes bibliográficos
Main Authors: Haynes, Robin L., van Leyen, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860095/
https://ncbi.nlm.nih.gov/pubmed/23838566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000350230
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