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p53-Based cyclotherapy: exploiting the ‘guardian of the genome' to protect normal cells from cytotoxic therapy

Side effects of chemotherapy are a major impediment in the treatment of cancer. Cyclotherapy is an emerging therapeutic strategy for protecting normal cells from the side effects of chemotherapy. Low, non-genotoxic doses of known p53 activators can be used to induce p53-dependent cell cycle arrest i...

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Bibliografiske detaljer
Main Authors: Rao, B, Lain, S, Thompson, A M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859955/
https://ncbi.nlm.nih.gov/pubmed/24231949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.702
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