A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells

BACKGROUND: Dynamin 2 (Dyn2) is a ~100 kDa GTPase that assembles around the necks of nascent endocytic and Golgi vesicles and catalyzes membrane scission. Mutations in Dyn2 that cause Centronuclear Myopathy (CNM) have been shown to stabilize Dyn2 polymers against GTP-dependent disassembly in vitro....

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Hlavní autoři: James, Nicholas G., Digman, Michelle A., Ross, Justin A., Barylko, Barbara, Wang, Lei, Li, Jinhui, Chen, Yan, Mueller, Joachim D., Gratton, Enrico, Albanesi, Joseph P., Jameson, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859711/
https://ncbi.nlm.nih.gov/pubmed/24016602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.09.001
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