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The Wobbler Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Displays Hippocampal Hyperexcitability, and Reduced Number of Interneurons, but No Presynaptic Vesicle Release Impairments

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. It is a fatal degenerative disease, best recognized for its debilitating neuromuscular effects. ALS however also induces cognitive impairments in as many as 50% of affected individuals. Moreover, many ALS patien...

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Detalhes bibliográficos
Main Authors: Thielsen, Karina D., Moser, Jakob M., Schmitt-John, Thomas, Jensen, Morten S., Jensen, Kimmo, Holm, Mai Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859636/
https://ncbi.nlm.nih.gov/pubmed/24349357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082767
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