Single-copy transgenic mice with chosen-site integration.

We describe a general way of introducing transgenes into the mouse germ line for comparing different sequences without the complications of variation in copy number and insertion site. The method uses homologous recombination in embryonic stem (ES) cells to generate mice having a single copy of a tr...

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Bibliografiske detaljer
Main Authors: Bronson, S K, Plaehn, E G, Kluckman, K D, Hagaman, J R, Maeda, N, Smithies, O
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC38596/
https://ncbi.nlm.nih.gov/pubmed/8799155
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