von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3

von Willebrand disease type 2B (vWD-type 2B) is characterized by gain-of-function mutations in von Willebrand factor (vWF) that enhance its binding to the glycoprotein Ib-IX-V complex on platelets. Patients with vWD-type 2B have a bleeding tendency that is linked to loss of vWF multimers and/or thro...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Casari, Caterina, Berrou, Eliane, Lebret, Marilyne, Adam, Frédéric, Kauskot, Alexandre, Bobe, Régis, Desconclois, Céline, Fressinaud, Edith, Christophe, Olivier D., Lenting, Peter J., Rosa, Jean-Philippe, Denis, Cécile V., Bryckaert, Marijke
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859410/
https://ncbi.nlm.nih.gov/pubmed/24270421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69458
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi