von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3

von Willebrand disease type 2B (vWD-type 2B) is characterized by gain-of-function mutations in von Willebrand factor (vWF) that enhance its binding to the glycoprotein Ib-IX-V complex on platelets. Patients with vWD-type 2B have a bleeding tendency that is linked to loss of vWF multimers and/or thro...

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Bibliographische Detailangaben
Hauptverfasser: Casari, Caterina, Berrou, Eliane, Lebret, Marilyne, Adam, Frédéric, Kauskot, Alexandre, Bobe, Régis, Desconclois, Céline, Fressinaud, Edith, Christophe, Olivier D., Lenting, Peter J., Rosa, Jean-Philippe, Denis, Cécile V., Bryckaert, Marijke
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859410/
https://ncbi.nlm.nih.gov/pubmed/24270421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69458
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