Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia shortening, and mucociliary clearance disruption. Exposure to CS reduced cilia length and induced autophagy in vivo and in...

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Main Authors: Lam, Hilaire C., Cloonan, Suzanne M., Bhashyam, Abhiram R., Haspel, Jeffery A., Singh, Anju, Sathirapongsasuti, J. Fah, Cervo, Morgan, Yao, Hongwei, Chung, Anna L., Mizumura, Kenji, An, Chang Hyeok, Shan, Bin, Franks, Jonathan M., Haley, Kathleen J., Owen, Caroline A., Tesfaigzi, Yohannes, Washko, George R., Quackenbush, John, Silverman, Edwin K., Rahman, Irfan, Kim, Hong Pyo, Mahmood, Ashfaq, Biswal, Shyam S., Ryter, Stefan W., Choi, Augustine M.K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859407/
https://ncbi.nlm.nih.gov/pubmed/24200693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69636
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