Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia shortening, and mucociliary clearance disruption. Exposure to CS reduced cilia length and induced autophagy in vivo and in...

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Detalhes bibliográficos
Main Authors: Lam, Hilaire C., Cloonan, Suzanne M., Bhashyam, Abhiram R., Haspel, Jeffery A., Singh, Anju, Sathirapongsasuti, J. Fah, Cervo, Morgan, Yao, Hongwei, Chung, Anna L., Mizumura, Kenji, An, Chang Hyeok, Shan, Bin, Franks, Jonathan M., Haley, Kathleen J., Owen, Caroline A., Tesfaigzi, Yohannes, Washko, George R., Quackenbush, John, Silverman, Edwin K., Rahman, Irfan, Kim, Hong Pyo, Mahmood, Ashfaq, Biswal, Shyam S., Ryter, Stefan W., Choi, Augustine M.K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859407/
https://ncbi.nlm.nih.gov/pubmed/24200693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69636
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