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Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia shortening, and mucociliary clearance disruption. Exposure to CS reduced cilia length and induced autophagy in vivo and in...

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主要な著者: Lam, Hilaire C., Cloonan, Suzanne M., Bhashyam, Abhiram R., Haspel, Jeffery A., Singh, Anju, Sathirapongsasuti, J. Fah, Cervo, Morgan, Yao, Hongwei, Chung, Anna L., Mizumura, Kenji, An, Chang Hyeok, Shan, Bin, Franks, Jonathan M., Haley, Kathleen J., Owen, Caroline A., Tesfaigzi, Yohannes, Washko, George R., Quackenbush, John, Silverman, Edwin K., Rahman, Irfan, Kim, Hong Pyo, Mahmood, Ashfaq, Biswal, Shyam S., Ryter, Stefan W., Choi, Augustine M.K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2013
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859407/
https://ncbi.nlm.nih.gov/pubmed/24200693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69636
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