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Role of Lysyl Oxidase Propeptide in Secretion and Enzyme Activity

Lysyl oxidase (LOX) is secreted as a proenzyme (proLOX) that is proteolytically processed in the extracellular milieu to release the propeptide and mature, active LOX. LOX oxidizes lysyl residues of a number of protein substrates in the extracellular matrix and on the cell surface, which impacts sev...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Grimsby, Jessica L., Lucero, Hector A., Trackman, Philip C., Ravid, Katya, Kagan, Herbert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858906/
https://ncbi.nlm.nih.gov/pubmed/20717923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22845
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