Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios(+) T cells and autoantibodies

Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1(Anaef), with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1(Anaef) mice exhibit anti-nuclear autoantibodies and gradually accumulate a CD44(hi...

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Main Authors: Daley, Stephen R, Coakley, Kristen M, Hu, Daniel Y, Randall, Katrina L, Jenne, Craig N, Limnander, Andre, Myers, Darienne R, Polakos, Noelle K, Enders, Anselm, Roots, Carla, Balakishnan, Bhavani, Miosge, Lisa A, Sjollema, Geoff, Bertram, Edward M, Field, Matthew A, Shao, Yunli, Andrews, T Daniel, Whittle, Belinda, Barnes, S Whitney, Walker, John R, Cyster, Jason G, Goodnow, Christopher C, Roose, Jeroen P
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2013
主題:
Biochemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858598/
https://ncbi.nlm.nih.gov/pubmed/24336796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01020
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