Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes

IgD and IgM are produced by alternative splicing of long primary RNA transcripts from the Ig heavy chain (Igh) locus and serve as the receptors for antigen on naïve mature B lymphocytes. IgM is made selectively in immature B cells, whereas IgD is coexpressed with IgM when the cells mature into folli...

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Detalhes bibliográficos
Main Authors: Enders, Anselm, Short, Alanna, Miosge, Lisa A., Bergmann, Hannes, Sontani, Yovina, Bertram, Edward M., Whittle, Belinda, Balakishnan, Bhavani, Yoshida, Kaoru, Sjollema, Geoff, Field, Matthew A., Andrews, T. Daniel, Hagiwara, Hiromi, Goodnow, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970522/
https://ncbi.nlm.nih.gov/pubmed/24616512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402739111
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