Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

Most normal cells have two centrosomes that form bipolar spindles during mitosis, while cancer cells often contain more than two, or “supernumerary” centrosomes. Such cancer cells achieve bipolar division by clustering their centrosomes into two functional poles, and inhibiting this process then lea...

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Main Authors: Kawamura, Eiko, Fielding, Andrew B., Kannan, Nagarajan, Balgi, Aruna, Eaves, Connie J., Roberge, Michel, Dedhar, Shoukat
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2013
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858562/
https://ncbi.nlm.nih.gov/pubmed/24091544
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