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Brain antigen-reactive CD4(+) T cells are sufficient to support learning behavior in mice with limited T cell repertoire

Numerous methods of T cell depletion lead to impairment of learning and memory function in mice. While adoptive transfer of whole splenocytes rescues learning behavior impairments, the precise sub-population and antigenic specificity of the T cells mediating the rescue remains unknown. Using several...

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Detalhes bibliográficos
Main Authors: Radjavi, Ali, Smirnov, Igor, Kipnis, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858511/
https://ncbi.nlm.nih.gov/pubmed/24012647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2013.08.013
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