Enhanced ER entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination

Efficient cross-presentation of protein antigens to cytotoxic T lymphocytes (CTLs) by dendritic cells (DCs) is essential for the success of prophylactic and therapeutic vaccines. Here, we report a previously underappreciated pathway involving antigen entry into the endoplasmic reticulum (ER) critica...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Hongxia, Yu, Xiaofei, Guo, Chunqing, Zuo, Daming, Fisher, Paul B., Subjeck, John R., Wang, Xiang-Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858385/
https://ncbi.nlm.nih.gov/pubmed/24218449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302312
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