Elevated Levels of Interferon-γ Production by Memory T Cells Do Not Promote Transplant Tolerance Resistance in Aged Recipients

Immunosenescence predisposes the elderly to infectious and autoimmune diseases and impairs the response to vaccination. We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike their young counterparts (8-12 weeks of age) aged male recipients (greater than 1...

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Autors principals: Kim, James I., Stott, Ryan T., Soohoo, Julie, Lee, Kang Mi, Zhao, Gaoping, Yeh, Heidi, Deng, Shaoping, Markmann, James F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858330/
https://ncbi.nlm.nih.gov/pubmed/24340063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082856
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