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Elevated Levels of Interferon-γ Production by Memory T Cells Do Not Promote Transplant Tolerance Resistance in Aged Recipients

Immunosenescence predisposes the elderly to infectious and autoimmune diseases and impairs the response to vaccination. We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike their young counterparts (8-12 weeks of age) aged male recipients (greater than 1...

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Main Authors: Kim, James I., Stott, Ryan T., Soohoo, Julie, Lee, Kang Mi, Zhao, Gaoping, Yeh, Heidi, Deng, Shaoping, Markmann, James F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858330/
https://ncbi.nlm.nih.gov/pubmed/24340063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082856
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