The Enhanced In Vivo Activity of the Combination of a MEK and a PI3K Inhibitor Correlates with [(18)F]-FLT PET in Human Colorectal Cancer Xenograft Tumour-Bearing Mice

Combined targeting of the MAPK and PI3K signalling pathways in cancer may be necessary for optimal therapeutic activity. To support clinical studies of combination therapy, 3′-deoxy-3′-[(18)F]-fluorothymidine ([(18)F]-FLT) uptake measured by Positron Emission Tomography (PET) was evaluated as a non-...

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Autori principali: Haagensen, Emma J., Thomas, Huw D., Wilson, Ian, Harnor, Suzannah J., Payne, Sara L., Rennison, Tommy, Smith, Kate M., Maxwell, Ross J., Newell, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858267/
https://ncbi.nlm.nih.gov/pubmed/24339963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081763
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