A SHORT SEQUENCE IMMEDIATELY UPSTREAM OF THE INTERNAL REPEAT ELEMENTS IS CRITICAL FOR KSHV LANA MEDIATED DNA REPLICATION AND IMPACTS EPISOME PERSISTENCE

Kaposi’s sarcoma-associated herpesvirus LANA (1162 residues) mediates episomal persistence of viral genomes during latency. LANA mediates viral DNA replication and segregates episomes to daughter nuclei. A 59 residue deletion immediately upstream of the internal repeat elements rendered LANA highly...

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Hauptverfasser: León Vázquez, Erika De, Juillard, Franceline, Rosner, Bernard, Kaye, Kenneth M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857964/
https://ncbi.nlm.nih.gov/pubmed/24314665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.10.026
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