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Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines

Aberrant imprinting of the insulin-like growth factor II (IGF2) gene is a molecular hallmark of many tumors. Reactivation of the normally suppressed maternal allele leads to upregulation of the growth factor that promotes tumor growth. However, the mechanisms underlying the loss of imprinting (LOI)...

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Autores principales: Li, Tao, Chen, Huiling, Li, Wei, Cui, Jiuwei, Wang, Guanjun, Hu, Xiang, Hoffman, Andrew R., Hu, Jifan
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857949/
https://ncbi.nlm.nih.gov/pubmed/23962719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt405
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