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Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines
Aberrant imprinting of the insulin-like growth factor II (IGF2) gene is a molecular hallmark of many tumors. Reactivation of the normally suppressed maternal allele leads to upregulation of the growth factor that promotes tumor growth. However, the mechanisms underlying the loss of imprinting (LOI)...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857949/ https://ncbi.nlm.nih.gov/pubmed/23962719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt405 |
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