Distinct effects of IPSU and suvorexant on mouse sleep architecture

Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, SB-649868, suvorexant (MK-4305), and filorexant (MK-6096), have shown promise for the treatment of insomnias and sleep disorders. Whether antagonism of both OX(1)R and OX(2)R is necessary for sleep induction has been a matter of some...

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Detalhes bibliográficos
Main Authors: Hoyer, Daniel, Dürst, Thomas, Fendt, Markus, Jacobson, Laura H., Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Laue, Grit, Ofner, Silvio, Legangneux, Eric, Gee, Christine E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857892/
https://ncbi.nlm.nih.gov/pubmed/24368893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2013.00235
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