Enhanced Trimethylation of Histone H3 Mediates Impaired Expression of Hepatic Glucose 6-Phosphatase Expression in Offspring From Rat Dams Exposed to Hypoxia During Pregnancy

Given that hepatic glucose 6-phosphatase (G6Pase, involved in gluconeogenesis) has been demonstrated to be altered long term in animal models of intrauterine growth restriction (IUGR), we hypothesized that hypoxia in utero may regulate G6Pase expression via epigenetic mechanisms. To address this fur...

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Hauptverfasser: Osumek, Jessica E., Revesz, Andrew, Morton, Jude S., Davidge, Sandra T., Hardy, Daniel B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857770/
https://ncbi.nlm.nih.gov/pubmed/23744881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1933719113492212
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