Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

We examined transcriptional and epigenetic mechanism(s) behind diminished skeletal muscle GLUT4 mRNA in intrauterine growth-restricted (IUGR) female rat offspring. An increase in MEF2D (inhibitor) with a decline in MEF2A (activator) and MyoD (co-activator) binding to the glut4 promoter in IUGR versu...

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Autores principales: Raychaudhuri, Nupur, Raychaudhuri, Santanu, Thamotharan, Manikkavasagar, Devaskar, Sherin U.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Transcription, Chromatin, and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376250/
https://ncbi.nlm.nih.gov/pubmed/18326493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800128200
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