Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers

Women with advanced stage ovarian cancer (OC) have a five-year survival rate of less than 25%. OC progression is associated with accumulation of epigenetic alterations and aberrant DNA methylation in gene promoters acts as an inactivating ?hit? during OC initiation and progression. Abnormal DNA meth...

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Detalhes bibliográficos
Main Authors: Huang, Rui-Lan, Gu, Fei, Kirma, Nameer B., Ruan, Jianhua, Chen, Chun-Liang, Wang, Hui-Chen, Liao, Yu-Ping, Chang, Cheng-Chang, Yu, Mu-Hsien, Pilrose, Jay M., Thompson, Ian M., Huang, Hsuan-Cheng, Huang, Tim Hui-Ming, Lai, Hung-Cheng, Nephew, Kenneth P.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857342/
https://ncbi.nlm.nih.gov/pubmed/23774800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.24816
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